| Match date | Home / Away | Opponent | Competition | Score | PL Points | |
| July 2009 | ||||||
| 15 Wed | Away | Exeter City | Pre-Season friendly | 0-3 | ||
| 17 Fri | Away | Bournmouth | Pre-Season friendly | 0-3 | ||
| 21 Tue | Away | Peterborough United | Pre-Season friendly | 0-4 | ||
| 24 Fri | Neutral | Barcelona | Wembley Cup | Pre-Season friendly | 1-1 | |
| 26 Sun | Neutral | Celtic | Wembley Cup | Pre-Season friendly | 0-2 | |
| 29 Wed | Neutral | West Ham United | Asia Cup | Pre-Season friendly | 1-0 | |
| 31 Fri | Neutral | Hull City | Asia Cup | Pre-Season friendly | 3-0 | |
| August 2009 | ||||||
| 02 Sun | Away | South China | Pre-Season friendly | 0-2 | ||
| 09 Sun | Home | Olympiakos | Pre-Season friendly | 3-0 | ||
| 16 Sun | Home | Liverpool | Barclays Premier League | Matchday 1 | 2-1 | 3 |
| 19 Wed | Away | Hull City | Barclays Premier League | Matchday 2 | 1-5 | 6 |
| 23 Sun | Away | West Ham United | Barclays Premier League | Matchday 3 | 1-2 | 9 |
| 26 Wed | Away | Doncaster Rovers | League cup | Round 2 | 1-5 | |
| 29 Sat | Home | Birmingham City | Barclays Premier League | Matchday 4 | 2-1 | 12 |
| September 2009 | ||||||
| 12 Sat | Home | Manchester United | Barclays Premier League | Matchday 5 | 1-3 | 12 |
| 20 Sun | Away | Chelsea | Barclays Premier League | Matchday 6 | 0-3 | 12 |
| 23 Wed | Away | Preston North End | League cup | Round 3 | 1-5 | |
| 26 Sat | Home | Burnley | Barclays Premier League | Matchday 7 | 5-0 | 15 |
| October 2009 | ||||||
| 03 Sat | Away | Bolton Wanderers | Barclays Premier League | Matchday 8 | 2-2 | 16 |
| 17 Sat | Away | Portsmouth | Barclays Premier League | Matchday 9 | 1-2 | 19 |
| 24 Sat | Home | Stoke City | Barclays Premier League | Matchday 10 | 0-1 | 19 |
| 27 Tue | Home | Everton | League cup | Round 4 | 2-0 | |
| 31 Sat | Away | Arsenal | Barclays Premier League | Matchday 11 | 3-0 | 19 |
| November 2009 | ||||||
| 07 Sat | Home | Sunderland | Barclays Premier League | Matchday 12 | 2-0 | 22 |
| 22 Sun | Home | Wigan Athletic | Barclays Premier League | Matchday 13 | 9-1 | 25 |
| 28 Sat | Away | Aston Villa | Barclays Premier League | Matchday 14 | 1-1 | 26 |
| December 2009 | ||||||
| 01 Tue | Away | Manchester United | League cup | Round 4 | 2-0 | |
| 06 Sun | Away | Everton | Barclays Premier League | Matchday 15 | 2-2 | 27 |
| 12 Sat | Home | Wolverhampton | Barclays Premier League | Matchday 16 | 0-1 | 27 |
| 15 Tue | Home | Manchester City | Barclays Premier League | Matchday 17 | 3-0 | 30 |
| 19 Sat | Away | Blackburn Rovers | Barclays Premier League | Matchday 18 | 0-2 | 33 |
| 26 Sat | Away | Fulham | Barclays Premier League | Matchday 19 | 0-0 | 34 |
| 28 Mon | Home | West Ham United | Barclays Premier League | Matchday 20 | 2-0 | 37 |
| January 2010 | ||||||
| 02 Sat | Home | Peterborough | FA Cup | Round 3 | 4-0 | |
| 16 Sat | Home | Hull City | Barclays Premier League | Matchday 21 | 0-0 | 38 |
| 20 Wed | Away | Liverpool | Barclays Premier League | Matchday 22 | 2-0 | 38 |
| 23 Sat | Home | Leeds United | FA Cup | Round 4 | 2-2 | |
| 26 Tue | Home | Fulham | Barclays Premier League | Matchday 23 | 2-0 | 41 |
| 30 Sat | Away | Birmingham City | Barclays Premier League | Matchday 24 | 1-1 | 42 |
| February 2010 | ||||||
| 03 Wed | Away | Leeds United | FA Cup | Replay | 1-3 | |
| 06 Sat | Home | Aston Villa | Barclays Premier League | Matchday 25 | 0-0 | 43 |
| 10 Wed | Away | Wolverhampton | Barclays Premier League | Matchday 26 | 1-0 | 43 |
| 14 Sun | Away | Bolton Wanderers | FA Cup | Round 5 | 1-1 | |
| 21 Sun | Away | Wigan Athletic | Barclays Premier League | Matchday 27 | 0-3 | 46 |
| 24 Wed | Home | Bolton Wanderers | FA Cup | Replay | 4-0 | |
| 28 Sun | Home | Everton | Barclays Premier League | Matchday 28 | 2-1 | 49 |
| March 2010 | ||||||
| 06 Sat | Away | Fulham | FA Cup | Round 6 | 0-0 | |
| 13 Sat | Home | Blackburn Rovers | Barclays Premier League | Matchday 29 | 3-1 | 52 |
| 20 Sat | Away | Stoke City | Barclays Premier League | Matchday 30 | 1-2 | 55 |
| 24 Wed | Home | Fulham | FA Cup | Replay | 3-1 | |
| 27 Sat | Home | Portsmouth | Barclays Premier League | Matchday 31 | 2-0 | 58 |
| April 2010 | ||||||
| 03 Sat | Away | Sunderland | Barclays Premier League | Matchday 32 | 3-1 | 58 |
| 11 Sun | Wembley | Portsmouth | FA Cup | Semi-Final | 2-0 | |
| 14 Wed | Home | Arsenal | Barclays Premier League | Matchday 33 | 2-1 | 61 |
| 17 Sat | Home | Chelsea | Barclays Premier League | Matchday 34 | 2-1 | 64 |
| 24 Sat | Away | Manchester United | Barclays Premier League | Matchday 35 | 3-1 | 64 |
| May 2010 | ||||||
| 01 Sat | Home | Bolton Wanderers | Barclays Premier League | Matchday 36 | 1-0 | 67 |
| 05 Wed | Away | Manchester City | Barclays Premier League | Matchday 37 | 0-1 | 70 |
| 09 Sun | Away | Burnley | Barclays Premier League | Matchday 38 | 4-2 | 70 |