| Match date | Home / Away | Opponent | Competition | Score | PL Points | |
| July 2010 | ||||||
| 10 Sat | Away | AFC Bournemouth | Pre-Season friendly | 0-4 | ||
| 17 Sat | Away | San Jose Earthquakes | Pre-Season friendly | 0-0 | ||
| 22 Thu | Away | New York Red Bulls | New York Challenge | Pre-Season friendly | 1-2 | |
| 25 Sun | Away | Sporting Lisbon | New York Challenge | Pre-Season friendly | 2-2 | |
| 28 Wed | Away | Leyton Orient | Pre-Season friendly | 2-2 | ||
| 29 Thu | Home | Villarreal | Pre-Season friendly | 1-4 | ||
| August 2010 | ||||||
| 03 Tue | Away | Benfica | Eusebio Cup | Pre-Season friendly | 0-1 | |
| 03 Tue | Away | Ipswich Town | Pre-Season friendly | 0-1 | ||
| 07 Sat | Home | Fiorentina | Pre-Season friendly | 3-2 | ||
| 10 Tue | Away | Hampton & Richmond Borough | Pre-Season friendly | 1-1 | ||
| 14 Sat | Home | Manchester City | Barclays Premier League | Matchday 1 | 1-1 | 1 |
| 17 Tue | Away | Young Boys (Switzerland) | Champions League | 1st leg play off match | 3-2 | |
| 21 Sat | Away | Stoke City | Barclays Premier League | Matchday 2 | 1-2 | 4 |
| 25 Wed | Home | Young Boys (Switzerland) | Champions League | 2nd leg play off match | 4-0 | |
| 28 Sat | Home | Wigan Athletic | Barclays Premier League | Matchday 3 | 0-1 | 4 |
| September 2010 | ||||||
| 11 Sat | Away | West Bromwich Albion | Barclays Premier League | Matchday 4 | 1-1 | 5 |
| 14 Tue | Away | Werder Bremen | Champions League | 1st group match | 2-2 | |
| 18 Sat | Home | Wolverhampton Wanderers | Barclays Premier League | Matchday 5 | 3-1 | 8 |
| 21 Tue | Home | Arsenal | League cup | 1-4 | ||
| 25 Sat | Away | West Ham United | Barclays Premier League | Matchday 6 | 1-0 | 8 |
| 29 Wed | Home | FC Twente | Champions League | 2nd group match | 4-1 | |
| October 2010 | ||||||
| 02 Sat | Home | Aston Villa | Barclays Premier League | Matchday 7 | 2-1 | 11 |
| 16 Sat | Away | Fulham | Barclays Premier League | Matchday 8 | 1-2 | 14 |
| 20 Wed | Away | Inter Milan | Champions League | 3rd group match | 4-3 | |
| 23 Sat | Home | Everton | Barclays Premier League | Matchday 9 | 1-1 | 15 |
| 30 Sat | Away | Manchester United | Barclays Premier League | Matchday 10 | 2-0 | 15 |
| November 2010 | ||||||
| 02 Tue | Home | Inter Milan | Champions League | 4th group match | 3-1 | |
| 06 Sat | Away | Bolton Wanderers | Barclays Premier League | Matchday 11 | 4-2 | 15 |
| 09 Tue | Home | Sunderland | Barclays Premier League | Matchday 12 | 1-1 | 16 |
| 13 Sat | Home | Blackburn Rovers | Barclays Premier League | Matchday 13 | 4-2 | 19 |
| 20 Sat | Away | Arsenal | Barclays Premier League | Matchday 14 | 2-3 | 22 |
| 24 Wed | Home | Werder Bremen | Champions League | 5th group match | 3-0 | |
| 28 Sun | Home | Liverpool | Barclays Premier League | Matchday 15 | 2-1 | 25 |
| December 2010 | ||||||
| 04 Sat | Away | Birmingham City | Barclays Premier League | Matchday 16 | 1-1 | 26 |
| 07 Tue | Home | FC Twente | Champions League | 6th group match | 3-3 | |
| 12 Sun | Home | Chelsea | Barclays Premier League | Matchday 17 | 1-1 | 27 |
| 26 Sun | Away | Aston Villa | Barclays Premier League | Matchday 18 | 1-2 | 30 |
| 28 Tue | Home | Newcastle United | Barclays Premier League | Matchday 19 | 2-0 | 33 |
| January 2011 | ||||||
| 01 Sat | Home | Fulham | Barclays Premier League | Matchday 20 | 1-0 | 36 |
| 05 Wed | Away | Everton | Barclays Premier League | Matchday 21 | 2-1 | 36 |
| 09 Sun | Home | Charlton Athletic | FA Cup | Round 3 | 3-0 | |
| 16 Sun | Home | Manchester United | Barclays Premier League | Matchday 22 | 0-0 | 37 |
| 22 Sat | Away | Newcastle United | Barclays Premier League | Matchday 23 | 1-1 | 38 |
| 30 Sun | Away | Fulham | FA Cup | Round 4 | 4-0 | |
| February 2011 | ||||||
| 02 Wed | Away | Blackburn Rovers | Barclays Premier League | Matchday 24 | 0-1 | 41 |
| 05 Sat | Home | Bolton Wanderers | Barclays Premier League | Matchday 25 | 2-1 | 44 |
| 12 Sat | Away | Sunderland | Barclays Premier League | Matchday 26 | 1-2 | 47 |
| 15 Tue | Away | AC Milan | Champions League | Rd of 16 1st leg | 0-1 | |
| 22 Tue | Away | Blackpool | Barclays Premier League | Matchday 27 | 3-1 | 47 |
| March 2011 | ||||||
| 06 Sun | Away | Wolverhampton Wanderers | Barclays Premier League | Matchday 28 | 3-3 | 48 |
| 09 Wed | Home | AC Milan | Champions League | Rd of 16 2nd leg | 0-0 | |
| 19 Sat | Home | West Ham United | Barclays Premier League | Matchday 29 | 0-0 | 49 |
| April 2011 | ||||||
| 02 Sat | Away | Wigan Athletic | Barclays Premier League | Matchday 30 | 0-0 | 50 |
| 05 Tue | Away | Real Madrid | Champions League | QF 1st leg | 4-0 | |
| 09 Sat | Home | Stoke City | Barclays Premier League | Matchday 31 | 3-2 | 53 |
| 13 Wed | Home | Real Madrid | Champions League | QF 2nd leg | 0-1 | |
| 20 Wed | Home | Arsenal | Barclays Premier League | Matchday 32 | 3-3 | 54 |
| 23 Sat | Home | West Bromwich Albion | Barclays Premier League | Matchday 33 | 2-2 | 55 |
| 30 Sat | Away | Chelsea | Barclays Premier League | Matchday 34 | 2-1 | 55 |
| May 2011 | ||||||
| 07 Sat | Home | Blackpool | Barclays Premier League | Matchday 35 | 1-1 | 56 |
| 10 Tue | Away | Manchester City | Barclays Premier League | Matchday 36 | 1-0 | 56 |
| 14 Sat | Away | Liverpool | Barclays Premier League | Matchday 37 | 0-2 | 59 |
| 22 Sun | Home | Birmingham City | Barclays Premier League | Matchday 38 | 2-1 | 62 |