| Match date | Home / Away | Opponent | Competition | Score | PL Points | |
| July 2015 | ||||||
| 29 Wed | Denver | MLS All stars | Pre-Season friendly | 2-1 | ||
| August 2015 | ||||||
| 04 Tue | Allianz Arena | Real Madrid | Audi Cup | 2-0 | ||
| 05 Wed | Allianz Arena | AC Milan | Audi Cup | 0-2 | ||
| 08 Sat | Away | Manchester United | Barclays Premier League | Matchday 1 | 1-0 | 0 |
| 15 Sat | Home | Stoke City | Barclays Premier League | Matchday 2 | 2-2 | 1 |
| 22 Sat | Away | Leicester City | Barclays Premier League | Matchday 3 | 1-1 | 2 |
| 29 Sat | Home | Everton | Barclays Premier League | Matchday 4 | 0-0 | 3 |
| September 2015 | ||||||
| 13 Sun | Away | Sunderland | Barclays Premier League | Matchday 5 | 0-1 | 6 |
| 17 Thu | Home | Qarabag | Europa League | 1st group match | 3-1 | |
| 20 Sun | Home | Crystal Palace | Barclays Premier League | Matchday 6 | 1-0 | 9 |
| 23 Wed | Home | Arsenal | Capital One Cup | 3rd Round | 0-1 | |
| 26 Sat | Home | Manchester City | Barclays Premier League | Matchday 7 | 4-1 | 12 |
| October 2015 | ||||||
| 01 Thu | Away | Monaco | Europa League | 2nd group match | 1-1 | |
| 04 Sun | Away | Swansea City | Barclays Premier League | Matchday 8 | 2-2 | 13 |
| 17 Sat | Home | Liverpool | Barclays Premier League | Matchday 9 | 0-0 | 14 |
| 22 Thu | Away | Anderlecht | Europa League | 3rd group match | 2-1 | |
| 25 Sun | Away | Bournemouth | Barclays Premier League | Matchday 10 | 1-5 | 17 |
| November 2015 | ||||||
| 02 Mon | Home | Aston Villa | Barclays Premier League | Matchday 11 | 3-1 | 20 |
| 05 Thu | Home | Anderlecht | Europa League | 4th group match | 2-1 | |
| 08 Sun | Away | Arsenal | Barclays Premier League | Matchday 12 | 1-1 | 21 |
| 22 Sun | Home | West Ham United | Barclays Premier League | Matchday 13 | 4-1 | 24 |
| 26 Thu | Away | Qarabag | Europa League | 5th group match | 0-1 | |
| 29 Sun | Home | Chelsea | Barclays Premier League | Matchday 14 | 0-0 | 25 |
| December 2015 | ||||||
| 05 Sat | Away | West Bromwich Albion | Barclays Premier League | Matchday 15 | 1-1 | 26 |
| 10 Thu | Home | Monaco | Europa League | 6th group match | 4-1 | |
| 13 Sun | Home | Newcastle United | Barclays Premier League | Matchday 16 | 1-2 | 26 |
| 19 Sat | Away | Southampton | Barclays Premier League | Matchday 17 | 0-2 | 29 |
| 26 Sat | Home | Norwich City | Barclays Premier League | Matchday 18 | 3-0 | 32 |
| 28 Mon | Away | Watford | Barclays Premier League | Matchday 19 | 1-2 | 35 |
| January 2016 | ||||||
| 03 Sun | Away | Everton | Barclays Premier League | Matchday 20 | 1-1 | 36 |
| 10 Sun | Home | Leicester City | FA Cup | 3rd round | 2-2 | |
| 13 Wed | Home | Leicester City | Barclays Premier League | Matchday 21 | 0-1 | 36 |
| 16 Sat | Home | Sunderland | Barclays Premier League | Matchday 22 | 4-1 | 39 |
| 20 Wed | Away | Leicester City | FA Cup | 3rd round replay | 0-2 | |
| 23 Sat | Away | Crystal Palace | Barclays Premier League | Matchday 23 | 1-3 | 42 |
| 30 Sat | Away | Colchester | FA Cup | 4th round | 1-4 | |
| February 2016 | ||||||
| 02 Tue | Away | Norwich City | Barclays Premier League | Matchday 24 | 0-3 | 45 |
| 06 Sat | Home | Watford | Barclays Premier League | Matchday 25 | 1-0 | 48 |
| 14 Sun | Away | Manchester City | Barclays Premier League | Matchday 26 | 1-2 | 51 |
| 18 Thu | Away | Fiorentina | Europa League | Round of 32 1st leg | 1-1 | |
| 21 Sun | Home | Crystal Palace | FA Cup | 5th round | 0-1 | |
| 25 Thu | Home | Fiorentina | Europa League | Round of 32 2nd leg | 3-0 | |
| 28 Sun | Home | Swansea City | Barclays Premier League | Matchday 27 | 2-1 | 54 |
| March 2016 | ||||||
| 02 Wed | Away | West Ham United | Barclays Premier League | Matchday 28 | 1-0 | 54 |
| 05 Sat | Home | Arsenal | Barclays Premier League | Matchday 29 | 2-2 | 55 |
| 10 Thu | Away | Borussia Dortmund | Europa League | Round of 16 1st leg | 3-0 | |
| 13 Sun | Away | Aston Villa | Barclays Premier League | Matchday 30 | 0-2 | 58 |
| 17 Thu | Home | Borussia Dortmund | Europa League | Round of 16 2nd leg | 1-2 | |
| 20 Sun | Home | Bournemouth | Barclays Premier League | Matchday 31 | 3-0 | 61 |
| April 2016 | ||||||
| 02 Sat | Away | Liverpool | Barclays Premier League | Matchday 32 | 1-1 | 62 |
| 10 Sun | Home | Manchester United | Barclays Premier League | Matchday 33 | 3-0 | 65 |
| 18 Mon | Away | Stoke City | Barclays Premier League | Matchday 34 | 0-4 | 68 |
| 25 Mon | Home | West Bromwich Albion | Barclays Premier League | Matchday 35 | 1-1 | 69 |
| May 2016 | ||||||
| 02 Mon | Away | Chelsea | Barclays Premier League | Matchday 36 | 2-2 | 70 |
| 08 Sun | Home | Southampton | Barclays Premier League | Matchday 37 | 1-2 | 70 |
| 15 Sun | Away | Newcastle United | Barclays Premier League | Matchday 38 | 5-1 | 70 |